Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case–control study

Table 3 The genotype and allele frequencies of IL-18 gene polymorphisms between HBV-HCC patients and controls

Polymorphisms	Cases, n = 153 (%)	Controls, n = 165 (%)	χ^2a	P value^a	OR^b	95% CI^b	P value^b
−607C/A
AA	37 (24.2)	41 (24.8)	0.088	0.957	1.0^ref	1.0^ref
AC	73 (47.7)	76 (46.1)			1.075	0.615–1.881	0.799
CC	43 (28.1)	48 (29.1)			1.024	0.534–1.963	0.943
A allele	147 (48.0)	158 (47.9)	0.957	0.968	1.0^ref	1.0^ref
C allele	159 (52.0)	172 (52.1)			1.006	0.737–1.374	0.968
P-_HWE	0.584	0.322
−137G/C
GG	122 (79.7)	106 (64.3)	9.468	0.008*	1.0^ref	1.0^ref
GC	28 (18.3)	54 (32.7)			0.506	0.290–0.882	0.016
CC	3 (2.0)	5 (3.0)			0.813	0.173–3.802	0.792
G allele	272 (88.9)	266 (80.6)	8.357	0.004*	1.0^ref	1.0^ref
C allele	34 (11.1)	64 (19.4)			0.520	0.332–0.814	0.004*
P-_HWE	0.363	0.548

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