Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis

Table 2 List of molecules that regulate miR cluster 143/145 in cancer

Regulatory molecules	Cancer type	Expression of these regulators in cancer	miRNA	References
Positive regulators
FoxO	RCC	Low	miR-145	[79]
p53	CRC, BrCa, PCa, HNSCC, Cervical	Low	miR-143, miR-145	[50, 83–85]
TGF-β1	GC	High	miR-143	[77]
BRCA1	BrCa	Low	miR-145	[80]
C/EBPβ	BrCa	Low	miR-143	[86]
PPARγ	CRC	Low	miR-145	[72]
Negative regulators
HPV-E6	HPV-induced cervical	High	miR-145	[88]
RREB1	CRC	High	miR-143, miR-145	[74]
KRAS	CRC, PaCa	High	miR-143, miR-145	[74]
EGFR	CRC	High	miR-143, miR-145	[73–76]
ERα	GC	High	miR-143, miR-145	[89, 90]
17-β-estradiol	BrCa	High	miR-143	[92, 93]
Estrogen	BrCa	High	miR-143, miR-145	[94]
FSH	EOC, cervical	High	miR-143	[176]
Adam17	RCC	High	miR-145	[96]
Sox2	Glioma, GCTs	High	miR-143, miR-145	[97]
Limk1	NSCLC	High	miR-143	[67]
DDX6	GC	High	miR-143, miR-145	[177]

CRC colorectal cancer, PCa prostate cancer, PaCa pancreatic cancer, BrCa breast cancer, GC gastric cancer, RCC renal cell carcinoma, HNSCC head and neck squamous cell carcinoma, EOC epithelial ovarian cancer, GCT germ cell tumor, NSCLC non-small cell lung carcinoma

ISSN: 1475-2867