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Table 2 List of molecules that regulate miR cluster 143/145 in cancer

From: Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis

Regulatory molecules Cancer type Expression of these regulators in cancer miRNA References
Positive regulators
FoxO RCC Low miR-145 [79]
p53 CRC, BrCa, PCa, HNSCC, Cervical Low miR-143, miR-145 [50, 8385]
TGF-β1 GC High miR-143 [77]
BRCA1 BrCa Low miR-145 [80]
C/EBPβ BrCa Low miR-143 [86]
PPARγ CRC Low miR-145 [72]
Negative regulators
HPV-E6 HPV-induced cervical High miR-145 [88]
RREB1 CRC High miR-143, miR-145 [74]
KRAS CRC, PaCa High miR-143, miR-145 [74]
EGFR CRC High miR-143, miR-145 [7376]
ERα GC High miR-143, miR-145 [89, 90]
17-β-estradiol BrCa High miR-143 [92, 93]
Estrogen BrCa High miR-143, miR-145 [94]
FSH EOC, cervical High miR-143 [176]
Adam17 RCC High miR-145 [96]
Sox2 Glioma, GCTs High miR-143, miR-145 [97]
Limk1 NSCLC High miR-143 [67]
DDX6 GC High miR-143, miR-145 [177]
  1. CRC colorectal cancer, PCa prostate cancer, PaCa pancreatic cancer, BrCa breast cancer, GC gastric cancer, RCC renal cell carcinoma, HNSCC head and neck squamous cell carcinoma, EOC epithelial ovarian cancer, GCT germ cell tumor, NSCLC non-small cell lung carcinoma