Fig. 1

Gene methylation and expression changes in S3 cells. a Survival of S3 and SiHa cells upon treatment with different concentrations of oxaliplatin as assessed by MTT assay. b Differences in gene expression between S3 and SiHa cells as revealed by protein levels in western blot analysis. c Differences in gene methylation and expression between S3 and SiHa cells. Methylation within the promoter regions (arrowheads) was measured by qMSP (upper panels). Corresponding changes in gene expression were detected by qRT-PCR (lower panel)