The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis

Table 4 Univariate and multivariate survival analyses for patients with OSCC

Variable	Univariate survival analysis			Multivariate survival analysis
Variable	Hazard ratio	95 % CI	p value	Hazard ratio	95 % CI	p value
Gender (male, female)	1.041	(0.385, 2.816)	0.937	1.228	(0.405, 3.722)	0.716
Age (≤60, >60)	1.276	(0.492, 3.308)	0.617	1.760	(0.597, 2.654)	0.306
Tumor size (T1–T2, T3–T4)	1.272	(0.490, 3.298)	0.621	0.450	(.083, 2.445)	0.355
Pathological grade (I, II–III)	0.536	(0.198, 1.454)	0.221	1.739	(0.616, 4.906)	0.284
Cervical nodal metastasis (N0, N+)	0.661	(0.251, 1.738)	0.401	0.370	(0.078, 1.770)	0.213
Clinical stage (I–II, III–IV)	1.770	(0.508, 6.162)	0.370	4.740	(0.638, 35.218)	0.128
LIN28B expression (low, high)	3.864	(0.883, 16.908)	0.073	4.905	(1.053, 22.846)	0.043 *

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