MicroRNA-7: a promising new target in cancer therapy

Table 1 The targets of miR-7 in different tumor types

Tumor type	Target site(s)	Reference(s)	Role of target site
Breast cancer	FAK, PAK1, EGFR, KLF4, HoxB3, SET8	[19, 21, 22, 24–26]	Suppressor
Lung cancer	PA28γ, BCL-2, EGFR, SLC7A5, HuR	[32, 35, 38 39]	Suppressor
Hepatocellular carcinoma	CCNE1, PI3KCD, mTOR, p70S6 K, GSK-3B	[48, 54]	Suppressor
Glioma	EGFR, C-KIT, FAK, ERK, ciRS-7	[42–44, 46]	Suppressor
Colorectal cancer	XRCC2, PAX6, YY1	[49, 52, 53]	Suppressor
Gastric cancer	EGFR, IGF1R	[42, 56]	Suppressor
Acute myelocytic leukemia	TET2	[58]	Suppressor
Urothelium carcinoma	FGFR3	[59]	Suppressor
Cervical cancer	XIAP	[60]	Suppressor
Renal carcinoma	None reported	[61]	Oncogene
Melanoma	IRS-2	[62]	Suppressor
Ovarian cancer	EGFR, ERK	[50]	Suppressor
Oral cancer	RECK	[63]	Oncogene
Neuroblastoma	4-HPR, EGCG	[64]	Suppressor
Pancreatic carcinoma	MAPK	[65]	suppressor
Pleural mesothelioma	None reported	[66]	Suppressor
Schwannoma tumors	EGFR, ACK1, PAK1	[67]	Suppressor
Tongue squamous carcinoma	IGF1R	[68]	Suppressor

FAK focal adhesion kinase, PAK1 p21 activated kinase 1, EGFR epidermal growth factor receptor, KLF4 Krüppel like factor 4, HoxB3 homeobox B3, SET8 SET domain-containing (lysine methyltransferase) 8, PA28γ proteasome activator 28 subunit γ, HuR human antigen R, PI3KCD phosphoinositide 3-kinase catalytic subunit delta, mTOR mammalian target of rapamycin, p70S6 K ribosomal protein S6 kinase, GSK-3β glycogen synthase kinase 3, ciRS-7 circular RNA sponge for miR-7, XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2, PAX6 paired box 6, YY1 Yin Yang 1, IGF1R insulin-like growth factor 1 receptor, TET2 tet methylcytosine dioxygenase 2, FGFR3 fibroblast growth factor receptor 3, XIAP X-linked inhibitor of apoptosis protein, IRS-2 insulin receptor substrate 2, RECK reversion-inducing cysteine-rich protein with Kazal motifs, 4-HPR N-(4-hydroxyphenyl) retinamide, EGCG (-)-epigallocatechin-3-gallate, MAPK mitogen-activated protein kinase, ACK1 associated cdc42 kinase 1

ISSN: 1475-2867