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Table 1 The targets of miR-7 in different tumor types

From: MicroRNA-7: a promising new target in cancer therapy

Tumor type Target site(s) Reference(s) Role of target site
Breast cancer FAK, PAK1, EGFR, KLF4, HoxB3, SET8 [19, 21, 22, 2426] Suppressor
Lung cancer PA28γ, BCL-2, EGFR, SLC7A5, HuR [32, 35, 38 39] Suppressor
Hepatocellular carcinoma CCNE1, PI3KCD, mTOR, p70S6 K, GSK-3B [48, 54] Suppressor
Glioma EGFR, C-KIT, FAK, ERK, ciRS-7 [4244, 46] Suppressor
Colorectal cancer XRCC2, PAX6, YY1 [49, 52, 53] Suppressor
Gastric cancer EGFR, IGF1R [42, 56] Suppressor
Acute myelocytic leukemia TET2 [58] Suppressor
Urothelium carcinoma FGFR3 [59] Suppressor
Cervical cancer XIAP [60] Suppressor
Renal carcinoma None reported [61] Oncogene
Melanoma IRS-2 [62] Suppressor
Ovarian cancer EGFR, ERK [50] Suppressor
Oral cancer RECK [63] Oncogene
Neuroblastoma 4-HPR, EGCG [64] Suppressor
Pancreatic carcinoma MAPK [65] suppressor
Pleural mesothelioma None reported [66] Suppressor
Schwannoma tumors EGFR, ACK1, PAK1 [67] Suppressor
Tongue squamous carcinoma IGF1R [68] Suppressor
  1. FAK focal adhesion kinase, PAK1 p21 activated kinase 1, EGFR epidermal growth factor receptor, KLF4 Krüppel like factor 4, HoxB3 homeobox B3, SET8 SET domain-containing (lysine methyltransferase) 8, PA28γ proteasome activator 28 subunit γ, HuR human antigen R, PI3KCD phosphoinositide 3-kinase catalytic subunit delta, mTOR mammalian target of rapamycin, p70S6 K ribosomal protein S6 kinase, GSK- glycogen synthase kinase 3, ciRS-7 circular RNA sponge for miR-7, XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2, PAX6 paired box 6, YY1 Yin Yang 1, IGF1R insulin-like growth factor 1 receptor, TET2 tet methylcytosine dioxygenase 2, FGFR3 fibroblast growth factor receptor 3, XIAP X-linked inhibitor of apoptosis protein, IRS-2 insulin receptor substrate 2, RECK reversion-inducing cysteine-rich protein with Kazal motifs, 4-HPR N-(4-hydroxyphenyl) retinamide, EGCG (-)-epigallocatechin-3-gallate, MAPK mitogen-activated protein kinase, ACK1 associated cdc42 kinase 1