Fig. 3

Growth factor-induced changes in MMP2 expression of HGSOC cell lines. a Total baseline levels of active MMPs in conditioned media was determined to vary across the cell lines when assayed with a fluorogenic MMP substrate. b Treatment with 10 ng/mL HB-EGF, NRG1β, IGF1, or HGF for 24 h impacted MMP2 expression in a subset of HGSOC cell lines. Expression levels were measured by qRT-PCR and fold change was determined using concurrently assayed GAPDH levels. Data presented as the average ± SD, n = 3. *p < 0.05 compared to vehicle