Fig. 4
From: Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
2-DG reduces tumor growth in KP2 xenograft model. a–b NSG mice were subcutaneously injected with 1 × 106 KP2 cells. Once the tumor was measurable, two groups of mice were treated by I.P. injection with 800 mg/ml 2-DG or PBS for 15 consecutive days. Representative images of tumors after treatment with PBS or 2-DG are shown (a). Quantification of tumors weight from tumors (P < 0.01) (b). c Ki67, Cleaved Caspase-3 and LC3II were analyzed by IHC in Paraffin-embedded sections of control or treated tumor tissues. d–f Quantitative analysis of Ki67 Cleaved–caspase3 and LC3II staining in xenograft tissue (P < 0.01)