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Table 1 Description of the cell lines and characterization of their responses to MTX

From: Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

Cell line

Gender

Age

Tumor type

Time of biopsy

DNA demethylation

Increased histone H3 acetylation

MTX + ATRA enhanced differentiation

Saos-2

F

11

N/A

N/A

Y

N

N

OSA-02

M

21

HGCC

DG

N

N

N

OSA-03

M

15

HGCC

DG

Y

N

Y

OSA-05

M

9

T

DG

Y

N

Y

OSA-06

F

16

O

DG

Y

Y

Y

OSA-08

M

10

O

DG

Y

N

N

  1. Gender: M male, F female; Age at the time of diagnosis: years; Tumor type: HGCC high grade conventional-chondroblastic, T teleangiectatic, O osteoblastic, N/A information not available; Time of biopsy: DG diagnostic, N/A information not available; Responses to MTX, i.e. DNA demethylation, histone H3 acetylation; enhanced matrix mineralization: Y yes, N no
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Cancer Cell International

ISSN: 1475-2867

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