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Table 1 Description of the cell lines and characterization of their responses to MTX

From: Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

Cell line Gender Age Tumor type Time of biopsy DNA demethylation Increased histone H3 acetylation MTX + ATRA enhanced differentiation
Saos-2 F 11 N/A N/A Y N N
OSA-02 M 21 HGCC DG N N N
OSA-03 M 15 HGCC DG Y N Y
OSA-05 M 9 T DG Y N Y
OSA-06 F 16 O DG Y Y Y
OSA-08 M 10 O DG Y N N
  1. Gender: M male, F female; Age at the time of diagnosis: years; Tumor type: HGCC high grade conventional-chondroblastic, T teleangiectatic, O osteoblastic, N/A information not available; Time of biopsy: DG diagnostic, N/A information not available; Responses to MTX, i.e. DNA demethylation, histone H3 acetylation; enhanced matrix mineralization: Y yes, N no