Fig. 4
From: SOX17 increases the cisplatin sensitivity of an endometrial cancer cell line
SOX17 induces mitochondrial apoptosis in EC cells after CDDP treatment. a Western blot experiments were performed to detect the levels of proteins. SOX17 overexpression increased the expression of cleaved caspase-3 and caspase-9. b CDDP regulated caspase-dependent apoptosis in HEC-1B cells. Cells were treated with 50 μM caspase-9 or caspse-3 inhibitor for 2 h and MTT analyses were performed after 48 h. c, d Down-regulated the p53-Bax-caspase-3 pathway in HEC-1B cells in vitro. Western blot analyses were performed to detect the protein levels of p53, Bax and cleaved caspase-3 (*P < 0.05)