Fig. 6
From: Temozolomide promotes genomic and phenotypic changes in glioblastoma cells
Long-term TMZ-treated cells have an individual pattern of expression/activation of the EMT markers and signal transduction pathway components. Proteins were evaluated by Western blot analysis with specific antibodies. AKT v-akt murine thymoma viral oncogene homolog 1, ASK1 mitogen-activated protein kinase kinase kinase 5, ERK mitogen-activated protein kinase, MGMT O-6-methylguanine-DNA methyltransferase, MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase, PARP poly (ADP-ribose) polymerase 1, Snail snail family zinc finger 1, Slug snail family zinc finger 2