Fig. 2
From: MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells
MiR-145 suppressed cell invasion and colony formation via decreasing the expression of Ang-2 in vitro. a Ectopic expression of miR-145 increased expression levels of miR-145 in BxPC3, MiaPaCa-2 and Panc-1 cells; b, c ectopic expression of miR-145 decreased the cell invasion and colony formation ability of BxPC3, MiaPaCa-2 and Panc-1 cells; d overexpression of miR-145 decreased Ang-2 protein levels in MiaPaCa-2 and Panc-1 cells but not in BxPC3 cells; e the expression of Ang-2 was lower in the supernatant of culture media of miR-145 over-expressing MiaPaCa-2 and Panc-1 cells when compared to control groups. Data represents the mean ± SEM, n = 3, significant differences between groups are indicated as *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired t test)