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Fig. 1 | Cancer Cell International

Fig. 1

From: Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Fig. 1

BMP2 is downregulated in CRC and it suppresses CRC cell proliferation and migration. a Expression of BMP2 in CRC (Log2) compared to adjacent normal tissue based on microarray data. Data are presented as mean ± S.E., n = 13. b Expression of BMP2 in control (n = 25), non-recurrent (n = 76), metastatic (n = 23), and metastatic recurrent (n = 24) from the GSE21510 CRC dataset. c qRT-PCR quantification of BMP2 expression in BMP2 HCT116 compared to LV control cells. Data are presented as mean ± S.D., n = 3. d Lentiviral-mediated re-expression of BMP2 in HCT116 cells reduces their cell viability. e Real time proliferation assay revealed significant decrease in the proliferation of BMP2 HCT116 compared to LV control cells in a time-dependent manner. f, g Conventional and real time migration assay showing significant inhibition of cell migration in the BMP2 HCT116 compared to LV control cells. The two-tailed t-test was used to compare different treatment groups. ***p < 0.0005

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Cancer Cell International

ISSN: 1475-2867

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