Table 1 Relationship between circulating tumor cells (CTCs) and clinicopathological characteristics in advanced colorectal cancer
Characteristics | No. of patients (%) | CTCs | P value | |
|---|---|---|---|---|
Positive | Negative | |||
All patients | 98 (100) | 48 (49.0) | 50 (51.0) | Â |
Gender | ||||
Male | 61 (62.2) | 31 (50.8) | 30 (49.2) | 0.640 |
Female | 37 (37.8) | 17 (45.9) | 20 (54.1) | |
Age (median 52, years) | ||||
<60 | 60 (61.2) | 30 (50.0) | 30 (50.0) | 0.800 |
≥60 | 38 (38.8) | 18 (47.4) | 20 (52.6) | |
Tumor size (cm) | ||||
<5 | 43 (43.9) | 20 (46.5) | 23 (53.5) | 0.666 |
≥5 | 55 (56.1) | 28 (50.9) | 27 (49.1) | |
Tumor location | ||||
Colon | 58 (59.2) | 29 (50.0) | 29 (50.0) | 0.808 |
Rectum | 40 (40.8) | 19 (47.5) | 21 (52.5) | |
Histology differentiation | ||||
Poor | 23 (23.5) | 18 (78.3) | 5 (21.7) | 0.043* |
Middle | 54 (55.1) | 23 (42.6) | 31 (57.4) | |
Well | 21 (21.4) | 7 (33.3) | 14 (66.7) | |
Depth of invasion | ||||
T1Â +Â T2 | 15 (15.3) | 6 (40.0) | 9 (60.0) | 0.135 |
T3 | 25 (25.5) | 11 (44.0) | 14 (56.0) | |
T4a | 47 (48.0) | 22 (46.8) | 25 (53.2) | |
T4b | 11 (11.2) | 9 (81.8) | 2 (18.2) | |
Lymphatic invasion | ||||
N0 | 30 (31.3) | 12 (38.7) | 19 (61.3) | 0.049* |
N1 | 22 (22.2) | 7 (31.8) | 15 (68.2) | |
N2a | 22 (22.2) | 13 (59.1) | 9 (40.9) | |
N2b | 24 (24.2) | 16 (66.7) | 8 (33.3) | |
TNM stage | ||||
III | 17 (17.3) | 4 (23.5) | 13 (76.5) | 0.023* |
IVa | 22 (22.5) | 9 (40.9) | 13 (59.1) | |
IVb | 59 (60.2) | 35 (59.3) | 24 (40.7) | |
CEA (ng/ml) | ||||
≤10 | 54 (55.1) | 20 (37.0) | 34 (63.0) | 0.014* |
>10 | 44 (44.9) | 28 (63.8) | 16 (36.4) | |
CA199 (U/ml) | ||||
≤37 | 57 (58.2) | 24 (42.1) | 33 (57.9) | 0.151 |
>37 | 41 (41.8) | 24 (58.5) | 17 (41.5) | |