Regulation of the hypoxic tumor environment in hepatocellular carcinoma using RNA interference

Table 2 Role of anti-apoptosis under hypoxia

Factors	Functions	Ref
Bcl family	Block BAX and BAD activity	[11, 51]
	Inhibited caspase activation	[5, 44]
	Inhibited cytochrome c release	[31, 48]
BNIP	Apoptotic protector	[15]
TGF-alpha	Induces epithelial development	[26]
TGF-alpha	Initiate multiple cell proliferation	[5, 44]
Caspase family	Downreulgation of caspase-3 and 9	[31, 48]
JNK	Regulates cell growth, differentiation, survival	[18, 51]
JNK	up-regulated STAT3	[44]

ISSN: 1475-2867