Fig. 3

The effect of MAPK inhibitors on BPIQ-induced anti-proliferation of lung cancer cells. H1299 cells were subject to treatment with BPIQ alone or MAPK specific inhibitors for 2 h prior to BPIQ administration for 24 h. The result of cellular survival assay is represented. Specific MAPK inhibitors, PD98059 for ERK, SP600125 for JNK, and SB203580 for p38 before BPIQ administration respectively. a Data were statistically analyzed with Student’s t test (*p < 0.05 BPIQ vs. BPIQ with inhibitor pre-treatments). b The ERK inhibitor rescues the decrease in cell number and morphological changes induced by BPIQ in H1299 cells. Magnification: 100×