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Fig. 7 | Cancer Cell International

Fig. 7

From: Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

Fig. 7

The regulation of cellular migration-associated proteins by BPIQ treatment. H1299 cells were subject to the treatment with indicated concentrations of BPIQ for 24 h. a Western Blot showed that sub-IC50 of BPIQ inhibits the phosphorylation of SP-1 and decreases the protein level of COX-2. β-actin as an internal control. Each blot is representative of three independent experiments. b The zymography assay. These results showed that BPIQ attenuates the activities of MMP enzymes especially MMP-2 in a dose-responsive manner. c The quantitative analysis of b indicates that sub-IC50 of BPIQ (less than 2 μM) significant inhibits MMPs activities. *p < 0.05 and **p < 0.01 against vehicle respectively

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Cancer Cell International

ISSN: 1475-2867

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