Table 1 Pathologic features and inhibition of cell growth by LEE011 in primary culture cells of pediatric ALL
|  | Gender | Age | Diagnosis | ALL typing | Chromosome analysis | Fusion gene | CDK6 | IC50 μM |
|---|---|---|---|---|---|---|---|---|
1 | F | 5 | ALL | B | 46, XX | Not detected | Positive | 2.14 |
2 | M | 4 | ALL, | B | 46, XY | TEL/AML1(+) | Positive | 1.73 |
3 | M | 3 | ALL | B | ALL/53–54, XY, +4, +6, +10, 12p+, +14, +17, +18, +20, +21 | Not detected | Positive | 14.68 |
4 | F | 4 | ALL | B | 46, XX | Not detected | Positive | 2.68 |
5 | F | 4 | ALL | B | ALL/53–55XX, +X, 1q+, +4, +6, +10, +11, +15, +17, +21 | Not detected | Positive | 11.52 |