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Table 1 Pathologic features and inhibition of cell growth by LEE011 in primary culture cells of pediatric ALL

From: Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

  Gender Age Diagnosis ALL typing Chromosome analysis Fusion gene CDK6 IC50 μM
1 F 5 ALL B 46, XX Not detected Positive 2.14
2 M 4 ALL, B 46, XY TEL/AML1(+) Positive 1.73
3 M 3 ALL B ALL/53–54, XY, +4, +6, +10, 12p+, +14, +17, +18, +20, +21 Not detected Positive 14.68
4 F 4 ALL B 46, XX Not detected Positive 2.68
5 F 4 ALL B ALL/53–55XX, +X, 1q+, +4, +6, +10, +11, +15, +17, +21 Not detected Positive 11.52