Table 2 Pathologic features and inhibition of cell growth by LEE011 in primary culture cells of pediatric AML
|  | Gender | Age | Diagnosis | AML typing | Chromosome analysis | Fusion gene | CDK6 | IC50 μM |
|---|---|---|---|---|---|---|---|---|
1 | F | 9 | AML | M4 | 46, XX | FLT3-ITD | Positive | 2.54 |
2 | F | 3 | AML | M4 | 46, XX, inv(16)(p13q22) | CBF/MYH11 | Positive | 8.46 |
3 | M | 4 | AML | M5b | 46, XY, −2, +10, t(10;10)(p13;q23) | MLL/AF10 | Positive | 1.94 |
4 | M | 12 | AML | M2a | 45, X, −Y, t(8;21)(q22;q22) | AML/ETO | Positive | 5.04 |
5 | F | 1 | AML | M4 | 46, XX, inv(16)(p13q22) | 46, XY, inv(16)(p13q22) | Positive | 2.98 |