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Table 2 Pathologic features and inhibition of cell growth by LEE011 in primary culture cells of pediatric AML

From: Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

  Gender Age Diagnosis AML typing Chromosome analysis Fusion gene CDK6 IC50 μM
1 F 9 AML M4 46, XX FLT3-ITD Positive 2.54
2 F 3 AML M4 46, XX, inv(16)(p13q22) CBF/MYH11 Positive 8.46
3 M 4 AML M5b 46, XY, −2, +10, t(10;10)(p13;q23) MLL/AF10 Positive 1.94
4 M 12 AML M2a 45, X, −Y, t(8;21)(q22;q22) AML/ETO Positive 5.04
5 F 1 AML M4 46, XX, inv(16)(p13q22) 46, XY, inv(16)(p13q22) Positive 2.98