Fig. 1

Gene expression profiles for six meningioma tissues. a Unsupervised hierarchical clustering showing Jed49_MN and Jed36_MN (group 1) tumors cluster separately to Jed04_MN, Jed18_MN, Jed34_MN and Jed40_MN (group 2). The latter are closer to normal brain gene expression (BN-1, BN-2 and BN-3) than Jed49_MN and Jed36_MN tumors. Cluster analysis shows 4472 differentially expressed probe sets (p < 0.005 and fold change >2.0). Color scheme for expression levels: red for comparably higher and green for comparably lower expression values. b The canonical pathway ‘Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency’ was identified as one of the top pathways related to a list of 404 probe sets which were differentially expressed between group 1 and group 2. The pathway was overlaid with the molecule activity predictor to pre-calculate further molecular effects, as outlined in the prediction legend