Table 4 Validation of the hub genes in TCGA database
From: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer
Category | Hub gene | Methylation status | P value | Expression status | P value |
|---|---|---|---|---|---|
Hypomethylation and high expression | |||||
|  | CAD | Hypomethylation | 5.55E−16 | Up-regulated | 3.88E−18 |
|  | CCND1 | Hypomethylation | 0.032 | Up-regulated | 7.26E−17 |
|  | ATM | – | – | Up-regulated | 0.006 |
|  | RB1 | Hypomethylation | 5.27E−03 | Up-regulated | 1.17E−11 |
|  | DNM2 | Hypomethylation | 1.36E−13 | Up-regulated | 5.23E−08 |
Hypermethylation and low expression | |||||
|  | EGFR | Hypermethylation | 4.65E−14 | Down-regulated | 7.20E−21 |
|  | ACTA1 | Hypermethylation | 1.64E−14 | – | – |
|  | SST | Hypermethylation | 9.67E−14 | Down-regulated | 2.22E−31 |
|  | ESR1 | Hypermethylation | 1.18E−14 | Down-regulated | 9.62E−20 |
|  | DNM2 | Hypermethylation | 5.43E−06 | – | – |