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Fig. 3 | Cancer Cell International

Fig. 3

From: Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway

Fig. 3

Colony formation (ae) and invasion (fj) results after siRNA-IL-6 knock down. As compared to the hep2-CSC group, siRNA-IL-6 or cisplatin treated hep2-CSC contained fewer cell colonies. The lowest degree of colony formation was observed when cisplatin treatment was combined with siRNA-IL-6. The siRNA-IL-6 or cisplatin treated hep2-CSC showed less invasion as compared with the hep2-CSC control. Again, the combination of cisplatin treatment with siRNA-IL-6 produced the lowest amount of invasion among the four groups. **p < 0.01, ***p < 0.001 vs hep2-CSC control; #p < 0.05, ##p < 0.01, ###p < 0.001 vs siRNA-IL6 group; ^^^p < 0.001 vs cisplatin group

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