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Fig. 7 | Cancer Cell International

Fig. 7

From: Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway

Fig. 7

IL-6 (a–d), STAT3 (e–h) and HIF1 (i–l) protein levels as detected with immunohistochemistry in xenograft cancer tissues derived from hep2-CSC, hep2-CSC-siRNA-IL-6, hep2-CSC + cisplatin and hep2-CSC-siRNA-IL-6 + cisplatin. Image analysis results showed that the number of IL-6+, STAT3+ and HIF1+ cells (m–o) was decreased in response to siRNA-IL-6 or cisplatin-treated xenografts. Maximal reductions in IL-6+, STAT3+ and HIF1+ cell numbers were obtained in the group receiving the combined treatment of siRNA-IL-6 and cisplatin. *p < 0.05, ***p < 0.001 vs hep2-CSC control

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Cancer Cell International

ISSN: 1475-2867

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