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Fig. 4 | Cancer Cell International

Fig. 4

From: miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling

Fig. 4

Assessment of the effect of miR-155-5p on apoptosis, cell cycle, proliferation, cell invasion and cell migration by CTHRC1 in HCCLM3 cells. a miR-155-5p triggered apoptosis via CTHRC1 in HCCLM3 cells. FACS plots in the left panel show the pattern of apoptosis in representative samples from each group. The statistical histogram is on the right panel. b miR-155-5p induced G0/G1 phase cell cycle arrest via CTHRC1 in HCCLM3 cells. Representative cell cycle profiles of each group are presented in the left panel. c miR-155-5p promoted cell proliferation via CTHRC1 in HCCLM3 cells. d miR-155-5p inhibited cell invasion via CTHRC1 in HCCLM3 cells. Representative images of each group in the Transwell invasion assay. Bar charts show the cell invasion ratio in the right panel. *p < 0.05. Scale bars = 100 μm. e miR-155-5p suppressed cell migration via CTHRC1 in HCCLM3 cells. Representative images of each group in the Transwell migration assay. Bar charts show the cell migration ratio in the right panel. *p < 0.05, scale bars = 100 μm

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Cancer Cell International

ISSN: 1475-2867

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