CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling

Table 2 Univariate and multivariate analyses of factors associated with overall survival of HCC patients

Factors	Univariate	Multivariate
Factors	P	Hazard ratio	95% CI	P
Age, years (≤ 50 vs > 50)	0.611
Gender (male vs female)	0.423
AFP (ng/mL) (> 20 vs ≤ 20)	0.249
ALT (U/mL) (> 75 vs ≤ 75)	0.598
GGT (U/mL) (> 45 vs ≤ 45)	0.314
Tumor size (cm) (> 5 vs ≤ 5)	0.009*	2.044	1.019–3.332	0.011*
Tumor multiplicity (multiple vs single)	0.134
Vascular invasion (yes vs no)	0.014*	2.218	0.891–3.013	0.033*
Tumor differentiation (I–II vs III–IV)	0.037*	1.877	1.035–2.821	0.098
TNM stage (I–II vs III)	0.003*	3.691	0.987–5.401	0.009*
CMTM5 expression (high vs low)	0.008*	3.087	1.012–4.392	0.013*

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