Table 1 Mechanism of natural agents that induce autophagy and apoptosis in cancer cells

Resveratrol

Ovarian cancer cells

STAT3

[52]

Ursolic acid

Prostate cancer cell

Beclin-1/Akt/mTOR

[62]

Colorectal cancer cells with p53 mutant

JNK

[47]

MCF-7 human breast cancer cells

EIF2AK3

[63]

Cervical cancer cells TC-1

ATG5

[64]

Tanshione IIA

KBM-5 leukemia cells.

mTOR/p70S6K/AMPK

[68]

Lung cancer 95D cells

ROS

[40]

Curcumin

Human colon cancer HCT116 cells

Transcription factor EB (TFEB)

[72]

Human melanoma cells

AKT/mTOR

[75]

Ginsenoside 20(S)-Rg3

Ovarian cancer

LC3II, ATG5, and ATG7

[46]

Fisetin

Prostate cancer cells

mTOR

[43]

Oridonin

Human cervical carcinoma Hela cells

ROS

[82]

Honokiol

Neuroblastoma cells

PI3K/Akt/mTOR

[45]

Piperlongumine

Myeloid leukemias

P38/ROS

[88]