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Fig. 3 | Cancer Cell International

Fig. 3

From: Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma

Fig. 3

The mRNA and protein levels of Gli1 and MGMT in U251 cells were significantly inhibited 48 h after treated by 5 μM cyclopamine (a and b). The MGMT promoter statement remained unchanged like the A172 treatment (c). When exposed to TMZ, cell viability treated with cyclopamine was significantly lower than that in the control 72 h after the treatment (d). The percentage of apoptotic cells in U251 cells treated with cyclopamine was significantly higher than in the control at 120 h post-treatment (e)

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Cancer Cell International

ISSN: 1475-2867

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