Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma

Table 1 Tumor growth in the four groups of nude mice

Groups	Tumor volume in 30 days after the treatment by TMZ, cyclopamine, or both (mm³)
Groups	0	5	10	15	20	25	30
Control	54.4 ± 14.7	82.1 ± 27.4	119.1 ± 40.3	226.2 ± 73.5	371.2 ± 131.3	482.1 ± 207.3	612.2 ± 264.9
TMZ	60.4 ± 7.4	75.4 ± 15.5	109.0 ± 35.3	199.3 ± 67.2	334.4 ± 114.0	453.9 ± 149.9	568.3 ± 203.9
Cyclopamine	52.2 ± 7.5	73.5 ± 24.8	107.2 ± 39.0	169.9 ± 57.1	248.5 ± 67.1	293.3 ± 83.6	356.0 ± 106.8
Cyclopamine + TMZ	56.6 ± 7.7	76.8 ± 8.5	74.3 ± 7.0	76.0 ± 10.8	80.5 ± 15.3	83.6 ± 21.8	92.0 ± 37.5
Control vs. TMZ	p = 0.349	p = 0.613	p = 0.639	p = 0.472	p = 0.543	p = 0.746	p = 0.700
Control vs. cyclopamine	p = 0.721	p = 0.514	p = 0.581	p = 0.143	p = 0.055	p = 0.042	p = 0.036
Control vs. cyclopamine + TMZ	p = 0.733	p = 0.687	p = 0.05	p = 0.001	p < 0.001	p < 0.001	p < 0.001
TMZ vs. cyclopamine + TMZ	p = 0.546	p = 0.918	p = 0.119	p = 0.004	p = 0.001	p = 0.001	p = 0.001
Cyclopamine vs. cyclopamine + TMZ	p = 0.487	p = 0.801	p = 0.138	p = 0.02	p = 0.012	p = 0.026	p = 0.031

ISSN: 1475-2867