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Table 1 Genes up-regulated in the expression 5 times greater in PEM-resistant cells then in the parent cells

From: Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells

Gene

Ratio of the expression (PEM-resistant cells/parent cells)

H28-PEM/NCI-H28

H226-PEM/NCI-H226

Cardiac ankyrin repeat protein (CARP)

6.320

28.949

Adrenergic receptor β-2 (ADRB2)

8.997

21.626

Plasminogen activator inhibitor 1 (PAI1)

9.017

10.212

Integrin β-3 (ITGB3)

10.944

9.041

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)

7.787

7.233

Insulin-like growth factor binding protein-3 (IGFBP3)

10.861

5.174

  1. Candidate genes listed were confirmed for the differential mRNA expression levels both in paired cells