Fig. 11

The interactions between the drugs and Caspase-3(2XYH) in the binding site. Ten random poses of matrine docked into the active site of 2XYH (a). The binding modes of matrine in Caspase-3: at least two residues involved in the interactions in ten random poses, Gly122 and Cys163 (h-bonds) (b). Ten random poses of cisplatin docked into the same active site of 2XYH (c). The binding modes of cisplatin in Caspase-3: at least two residues involved in the interactions in ten random poses, Ser120 and Gln161 (h-bonds) (d)