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Table 1 Characteristics of studies included in the meta-analysis

From: Prognostic and clinicopathological significance of long noncoding RNA HOXA11-AS expression in human solid tumors: a meta-analysis

Authors Years Region Tumor type Sample type Sample size Preoperative treatment Tumor stage Method of HOXA11-AS expression Elevated HOXA11-AS Cut-off value Outcome measure Survival analysisa Methodb NOS score
Kim et al. 2016 [14, 17] Korea Cervical cancer Tissues 92 No FIGO I–III qRT-PCR Significantly higher (p < 0.05) Tenfold OS U, M 1 8
Sun et al. 2016 [31] China Gastric cancer Tissues 86 No TNM I–IV qRT-PCR Significantly higher (p < 0.01) Median OS, PFS U, M 1, 2 8
Wang et al. 2016 [26] China Glioblastoma Tissues 89 N/A N/A N/A Significantly higher (p < 0.01) Median OS U, M 1 6
Chen et al. 2017 [9, 27] China Non-small cell lung cancer Tissues 78 No TNM I–III qRT-PCR Significantly higher (p < 0.05) Median OS No 2 7
Cui et al. 2017 [16, 28] China Osteosarcoma Tissues 51 No TNM I–III qRT-PCR Significantly higher (p < 0.05) Median OS No 1 6
Xu et al. 2017 [32] China Glioma Tissues 45 N/A TNM I–IV qRT-PCR Significantly higher (p < 0.01) Median OS No 1 7
Yim et al. 2017 [29] Korea Serous ovarian cancer Tissues 129 No FIGO I–IV qRT-PCR Significantly higher (p < 0.05) Fold change OS, PFS M 1 7
Zhang et al. 2017 [30] TCGA Lung adenocarcinoma N/A 287 N/A TNM I–IV N/A Significantly higher (p < 0.001) N/A OS No 2 6
Lungsquamous cell carcinoma N/A 463 N/A TNM I–IV N/A Significantly higher (p < 0.001) N/A OS No 2 6
  1. N/A not available, TNM tumor/node/metastasis, FIGO International Federation of gynecology and obstetrics, qRT-PCR quantitative reverse transcription PCR, OS overall survival, PFS progression free survival, NOS Newcastle–Ottawa Scale
  2. aU denoted as univariate analysis; M denoted as multivariate analysis
  3. b1 denoted as obtaining HRs directly from publications; 2 denoted as extracting HRs from Kaplan–Meier curves