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Fig. 6 | Cancer Cell International

Fig. 6

From: MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma

Fig. 6

The putative schematic representation of pathway involved in miR-20a-5p-mediated suppression of cell proliferation in SH-SY5Y cells. MiR-20a-5p recognizes and binds to 3′-UTR of ATG7, repressing ATG7 gene translation. Since ATG7 contribute to autophagosome initiation and completion, which accounts for cell proliferation and anti-apoptosis, miR-20a-5p-mediated ATG7 inhibition thus results in cell proliferation suppression and further apoptosis

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