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Table 1 p53 mutations and protein overexpression in ovarian carcinoma

From: Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Tumor SSCP results Exon/intron Type Nucleotide AA change IHC results
2 + Intron 2 Substitution 15902 A<G   ++
3 +
+
Exon 3
Intron 2
Substitution
Substitution
16147 G<A
15963 A<T
L<K +++
4 + Exon 4 Substitution 16397 C<G P<R ++
5 +
+
Exon 4
Exon 7
Substitution
Substitution
16494 G<T
18330 C<T
G<V
R<W
+++
6 + Exon 4 Substitution 16397 C<G P<R +++
7 +
Exon 4
Intron 2
Substitution
Substitution
16397 C<G
15854 G<C
P<R ++
9
Exon 7
Exon 9
Substitution
Deletion
18429 T<G
19001
A<E ++
11
Exon 4
Intron 7
Substitution
Substitution
16397 C<G
18536 T<C
P<R ++
14 Intron 2 Substitution 15896 T<C   ++
15 +
Exon 3
Exon 4
Substitution
Substitution
16147 G–A
16397 C<G
L<K
P<R
+++
18 Intron 7 Substitution 18603 A<T   ++
25 + Exon 4 Substitution 16397 C<G P<R +++
29 + Intron 7 Substitution 18549 C<G   +++