Table 1 p53 mutations and protein overexpression in ovarian carcinoma
Tumor | SSCP results | Exon/intron | Type | Nucleotide | AA change | IHC results |
|---|---|---|---|---|---|---|
2 | + | Intron 2 | Substitution | 15902 A<G | ++ | |
3 | + + | Exon 3 Intron 2 | Substitution Substitution | 16147 G<A 15963 A<T | L<K | +++ |
4 | + | Exon 4 | Substitution | 16397 C<G | P<R | ++ |
5 | + + | Exon 4 Exon 7 | Substitution Substitution | 16494 G<T 18330 C<T | G<V R<W | +++ |
6 | + | Exon 4 | Substitution | 16397 C<G | P<R | +++ |
7 | + − | Exon 4 Intron 2 | Substitution Substitution | 16397 C<G 15854 G<C | P<R | ++ |
9 | − − | Exon 7 Exon 9 | Substitution Deletion | 18429 T<G 19001 | A<E | ++ |
11 | − − | Exon 4 Intron 7 | Substitution Substitution | 16397 C<G 18536 T<C | P<R | ++ |
14 | − | Intron 2 | Substitution | 15896 T<C | ++ | |
15 | + − | Exon 3 Exon 4 | Substitution Substitution | 16147 G–A 16397 C<G | L<K P<R | +++ |
18 | − | Intron 7 | Substitution | 18603 A<T | ++ | |
25 | + | Exon 4 | Substitution | 16397 C<G | P<R | +++ |
29 | + | Intron 7 | Substitution | 18549 C<G | +++ |