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Table 1 p53 mutations and protein overexpression in ovarian carcinoma

From: Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Tumor SSCP results Exon/intron Type Nucleotide AA change IHC results
2 + Intron 2 Substitution 15902 A<G   ++
3 + + Exon 3 Intron 2 Substitution Substitution 16147 G<A 15963 A<T L<K +++
4 + Exon 4 Substitution 16397 C<G P<R ++
5 + + Exon 4 Exon 7 Substitution Substitution 16494 G<T 18330 C<T G<V R<W +++
6 + Exon 4 Substitution 16397 C<G P<R +++
7 + − Exon 4 Intron 2 Substitution Substitution 16397 C<G 15854 G<C P<R ++
9 − − Exon 7 Exon 9 Substitution Deletion 18429 T<G 19001 A<E ++
11 − − Exon 4 Intron 7 Substitution Substitution 16397 C<G 18536 T<C P<R ++
14 Intron 2 Substitution 15896 T<C   ++
15 + − Exon 3 Exon 4 Substitution Substitution 16147 G–A 16397 C<G L<K P<R +++
18 Intron 7 Substitution 18603 A<T   ++
25 + Exon 4 Substitution 16397 C<G P<R +++
29 + Intron 7 Substitution 18549 C<G   +++