Skip to main content

Table 1 Comparative analysis of cell death (%) of monolayer and spheroid ACC cells analyzed by MTS assay

From: The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells

  Monolayer Spheroids
Treatmenta
 Mitotane 10 μM 30 μM 10 μM 30 μM
  0 86.9 0 15.4
 Mitotaneb     48.1
  + Mitotane (10 μM) + Mitotane (30 μM)
Everolimus (10 μM) 29.7 49.3 0 32.1
Sunitinib (5 μM) 58.2 76.2 20.3 23.6
Zol Acid (10 μM) 19.5 30.1 0 0
Imatinib (10 μM) 27.2 50.3 0 18.1
Nilotinib (10 μM) 62.8 70.2 39.6 56.0
Nilotinibb (10 μM) 67.2 62.5 62.0 60.0
  1. ACC adrenocortical carcinoma
  2. aFor 72 h
  3. bACC-T36