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Table 2 Familiar VEGFR tyrosine kinase inhibitors and their targets

From: Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma

TKI VEGFR-1 VEGFR-2 VEGFR-3 Other targets
Sorafenib   +   Raf-1, B-Raf, B-Raf (V599E)
Sunitinib   +   c-Kit, FLT3, PDGFRβ
Lenvatinib + + + PDGFRα, PDGFRβ, FGFR1
Cabozantinib [19]   +   c-MET, AXL, RET, KIT, FLT3, TRKB, Tie-2
Axitinib [21, 22] + + + PDGFRα, PDGFRβ, Kit, BCR-ABL1
Vandetanib   + + EGFR
Dovitinib + + + c-Kit, FLT3, FGFR1
Pazopanib + + + PDGFR, FGFR, c-Kit
Foretinib + + + MET, Tie2
Apatinib   +   RET