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Fig. 2 | Cancer Cell International

Fig. 2

From: Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1

Fig. 2

Rab11-FIP2 is important for motility and metastasis of HCT15 and HCT116 cells. a Overexpression of Rab11-FIP2 affects HCT15 and HCT116 cells migration in an in vitro wound assay. Average migratory width of three independent experiments is shown (*p < 0.05). b 15/FIP2 and 116/FIP2 cells or control vector cells were subjected to Transwell migration assays. The migrated cells through the membrane of each cell line are quantified. All results are from three independent experiments (*p < 0.05). c Overexpression of Rab11-FIP2 promoted colony formation in CRC cells. d Pathology analyses showed that overexpression of Rab11-FIP2 significantly increased lung metastasis of HCT15 and HCT116 cells in nude mice lung seeding assay

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