Fig. 2
From: Targeting FBPase is an emerging novel approach for cancer therapy
Regulation of FBPase. Acute regulation of FBPase is achieved mainly through allosteric regulator. Chronic regulation of FBPase occurs through transcriptional and hormonal regulation mainly by glucagon, glucocorticoid hormones and insulin. ADP adenosine diphosphate, AMP adenosine monophosphate, AKT protein kinase B, cAMP cyclic adenosine monophosphate, CBP CREB-binding protein, CREB cAMP response element-binding protein, CRTC2 CREB coactivator, G6P glucose-6-phosphate, GLUT2 glucose transportor 2, GCGR glucagon receptor, F1,6BP fructose-1,6-bisphosphate, F2,6BP fructose-2,6-bisphosphate, F6P fructose-6-phosphate, FBPase fructose-1,6-bisphosphatase, FOXO forkhead box O protein, HDAC histone deacetylase, LDHA lactate dehydrogenase A, MCT monocarboxylate transporters, PFK2/FBPase2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, PEP phosphoenolpyruvate, PFK1 phosphofructokinase-1, PKA protein kinase A, PKM2 pyruvate kinase M2, TIGAR TP53-induced glycolysis and apoptosis regulator, TCA tricarboxylic acid