Targeting FBPase is an emerging novel approach for cancer therapy

Table 2 Regulation of aberrant expression of FBP1 in cancer

Regulator	Interaction	Reference(s)
LSD1	Promoter methylation	[114]
NF-kappaB	Promoter methylation	[26]
NPM1	Promoter methylation	[28]
Snail-G9a-Dnmt1	Promoter methylation	[22]
ZEB1	Promoter methylation	[13]
HDAC1/2	Histone deacetylation	[81]
Copy number loss	Genomic alterations	[15, 86]
TRIM28	Ubiquitination degradation	[80]

ISSN: 1475-2867