Table 2 The pooled associations between LncRNA XIST expression and the prognosis of solid tumors
Outcome subgroup | Number of patients | Number of studies | Random-effect model | Heterogeneity | ||
|---|---|---|---|---|---|---|
HR (95% CI) | p value | I2 (%) | p value | |||
Overall survival | 1209 | 15 | 1.54 (1.07, 2.23) | 0.021 | 86.3 | < 0.001 |
Tumor type | ||||||
Digestive system | 630 | 7 | 1.67 (1.11, 2.51) | 0.014 | 80.5 | < 0.001 |
Non-digestive system | 579 | 8 | 1.39 (0.71, 2.74) | 0.339 | 90.1 | < 0.001 |
Patients’ number | ||||||
> 65 | 836 | 8 | 1.75 (1.24, 2.47) | 0.001 | 78.2 | < 0.001 |
≤ 65 | 373 | 7 | 1.26 (0.53, 3.01) | 0.598 | 91.4 | < 0.001 |
Analysis type | ||||||
Univariate analysis | 781 | 10 | 1.21 (0.75, 1.95) | 0.436 | 84.8 | < 0.001 |
Multivariate analysis | 428 | 5 | 2.39 (1.28, 4.46) | 0.006 | 89.2 | < 0.001 |
HR obtained method | ||||||
Reported in text | 534 | 6 | 2.50 (1.49, 4.18) | 0.000 | 87.5 | < 0.001 |
Data extrapolated | 675 | 9 | 1.07 (0.66, 1.76) | 0.774 | 82.2 | < 0.001 |