Table 2 List of drug transport systems and their status in HCC
From: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
S. No. | Transporter | Mode of action | Up-regulated or down-regulated | References |
|---|---|---|---|---|
1 | MDR1 (ABCB1 or P-glycoprotein), MRP1 (ABCC1), MRP2 (ABCC2), MRP3(ABCC3) and ABCG2 | Extrudes unrelated anti-tumoral agents like anthracyclines, taxanes, vinca alkaloids etc. from the cell | Up regulated | |
2 | OATP1B1 and OATP1B3 | Transports anti-tumor drugs inside the cells | Down regulated | |
3 | SLC28 and SLC29 | Uptake of nucleoside derived anticancer drugs | Down regulated | [103] |
4 | Organic cationic transporter-1 (OCT1) | Uptake of tyrosine kinase inhibitors | Down regulated; hyper-methylation of the SLC22A1 promoter | [104] |