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Table 4 Cumulative effects of rs4848320-T and rs1110839-G on lung cancer and non-small cell lung cancer susceptibility

From: Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer

Variant

Controls (%) (593)

Lung cancer

Non-small cell lung cancer

Cases (%) (434)

ORa (95% CI)

P value

Cases (%) (331)

ORa (95% CI)

P value

No. of alleles

 0 (ref)

232 (39.1)

168 (38.7)

1.00 (ref)

 

129 (39.0)

1.00 (ref)

 

 1

174 (29.3)

115 (26.5)

0.893 (0.654–1.218)

0.474

85 (25.7)

0.871 (0.619–1.225)

0.427

 2

132 (22.3)

112 (25.8)

1.167 (0.846–1.612)

0.346

88 (26.6)

1.207 (0.852–1.710)

0.291

 3–4

55 (9.3)

39 (9.0)

0.985 (0.622–1.560)

0.948

29 (8.8)

0.947 (0.572–1.569)

0.833

Trend

  

Pb = 0.893

  

Pb = 0.964

 

 0

232 (39.1)

168 (38.7)

1.00 (ref)

 

129 (39.0)

1.00 (ref)

 

 1–4

361 (60.9)

266 (61.3)

1.007 (0.780–1.301)

0.955

202 (61.0)

1.005 (0.761–1.328)

0.971

  1. OR odds ratio, CI confident interval
  2. ORa was adjusted by age, gender and smoking
  3. b P value was calculated by linear-by-linear association of χ2 test