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Table 5 Stratified analyses of association between the two SNPs and lung cancer risk by smoking exposure

From: Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer

SNP Genotype Smoking exposure Controls (%) Cases (%) ORª (95% CI) P value
Rs4848320 CC Ever 88 (74.6) 58 (60.4) 1.00 (ref)  
CT   29 (24.6) 32 (33.3) 1.695 (0.922–3.119) 0.090
TT   1 (0.8) 6 (6.3) 8.219 (0.957–70.618) 0.055
CT + TT vs CC     1.929 (1.070–3.479) 0.029
TT vs CT + CC     7.048 (0.827–60.092) 0.074
CC Never 314 (66.1) 233 (68.9) 1.00 (ref)  
CT   146 (30.7) 99 (29.3) 0.914 (0.671–1.245) 0.568
TT   15 (3.2) 6 (1.8) 0.563 (0.213–1.484) 0.245
CT + TT vs CC     0.882 (0.653–1.192) 0.415
TT vs CT + CC     0.578 (0.220–1.519) 0.266
Rs1110839 TT Ever 50 (42.4) 30 (31.3) 1.00 (ref)  
TG   62 (52.5) 53 (55.2) 1.376 (0.763–2.482) 0.288
GG   6 (5.1) 13 (13.5) 3.224 (1.089–9.544) 0.034
TG + GG vs TT     1.539 (0.867–2.731) 0.141
GG vs TG + TT     2.652 (0.954–7.371) 0.062
TT Never 200 (42.1) 144 (42.6) 1.00 (ref)  
TG   212 (44.6) 156 (46.2) 1.010 (0.748–1.364) 0.950
GG   63 (13.3) 38 (11.2) 0.847 (0.534–1.341) 0.478
TG + GG vs TT     0.973 (0.731–1.294) 0.849
GG vs TG + TT     0.842 (0.546–1.299) 0.437
  1. SNP single nucleotide polymorphism, OR odds ratio, CI confident interval
  2. ORa was adjusted by age and gender