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Fig. 4 | Cancer Cell International

Fig. 4

From: Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

Fig. 4

Detection of the migration abilities of gastric cancer cells. BGC-823, MKN-45 and SGC-7901 cells were co-cultured with GCAFs or CM from GCAFs for 72 h before the wounds were generated. Additionally, the scratch area after 48 h was measured to evaluate the migration abilities of cancer cells (scale bar = 500 µm). a Cells cultured in DMEM with 5% FBS were used as the control. b Alterations of BGC-823 cells treated with CAF-2916, CAF-2922, and CAF-2923. c Ratios of the migration area of gastric cancer cells (BGC-823, MKN-45 and SGC-7901) treated with activated GCAFs compared with those of the control group after 48 h (normalized). *P < 0.05, **P < 0.01

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