Fig. 1
From: PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression
Genomic information of human PEG10 gene. PEG10 gene is located on the q21.3 of chromosome 7. The bold arrows show the orientations of PEG10 and SGCE. Exon 1 transcribes the 5’-UTR and exon 2 transcribes two ORFs and the 3’-UTR. ORF1 encodes a gag-like PEG10-RF1 protein, which contains a CCHC-type zinc finger domain. This component protein regulates cell proliferation and apoptosis as a main functional protein. By -1 frameshift translation, the ORF1 and the ORF2 translated PEG10-RF1/2 fusion protein with an aspartic protease motif