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Fig. 1 | Cancer Cell International

Fig. 1

From: Establishment and characterization of three stable Basal/HER2-positive breast cancer cell lines derived from Chinese breast carcinoma with identical missense mutations in the DNA-binding domain of TP53

Fig. 1

Phase-contrast microscopy and Transmission electron micrograph of cultured ZJU-0327, ZJU-0725 and ZJU-1127 cells. (ac, ×100) ZJU-0327, ZJU-0725, and ZJU-1127 cells grew directly from explant 48 h after seeding. (df, ×100; gi, ×200) At P72 of ZJU-0327, ZJU-0725, and ZJU-1127cells formed a monolayer and exhibited typical characteristics of malignancy, including numerous mitotic bodies, a high nuclear-to-cytoplasm ratio, prominent nucleoli, occasional multinucleated giant cells (indicated by the arrows), cytoplasmic vacuoles. (jl, ×5000) ZJU-0327, ZJU-0725, and ZJU-1127 cells revealed identical ultrastructural features including desmosomes, a sunken nuclear membrane, tonofilaments, cytoplasmic inclusions, and numerous organelles in the cytoplasm

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