ZFAS1: a novel tumor-related long non-coding RNA

Table 1 Functional characterization of ZFAS1 in various tumors

Tumor type	Expression	Functional role	Related gene	Role	References
Breast cancer	Downregulation	–	–	Tumor suppressor	[16, 19, 21, 22]
Glioma	Upregulation	Proliferation, migration invasion, cell cycle, EMT process	E-Cadherin, N-cadherin, Snail, MMP2, MMP9, Integrin β1, ZEB1, Twist, HES-1, NICD	Oncogene	[25, 26]
Colorectal cancer	Upregulation	Proliferation, cell cycle, invasion, apoptosis, EMT process	miR-484, p53, cyclin B1, PARP, ZEB1, E-cadherin, ZO-1, Vimentin, N-cadherin	Oncogene	[30,31,32,33]
Gastric cancer	Upregulation	Proliferation, cell cycle, migration, apoptosis, EMT process	N-Cadherin, Vimentin, ZEB1, Snail, MMP14, Twist, E-cadherin, EpCAM, Cyclin D1, Bcl2, Bax, Slug,	Oncogene	[37,38,39]
Hepatocellular carcinoma	Upregulation/downregulation	Proliferation, apoptosis, invasion, metastasis	ZEB1, MMP-14, MMP16, miR-9, miR-150	Oncogene/tumor suppressor	[41, 42]
Ovarian cancer	Upregulation	Proliferation, migration, chemoresistance	miR-150, Sp1	Oncogene	[45, 46]
Melanoma	Upregulation	Proliferation	Ki67, PCNA, CyclinD1	Oncogene	[47]
Non-small cell lung cancer	Upregulation	–	–	Oncogene	[48]
Osteosarcoma	Upregulation	Proliferation, invasion	miR-200b, miR-200c, BMI1, Sp1, ZEB2	Oncogene	[49]
Esophageal squamous cell carcinoma	Upregulation	–	–	Oncogene	[50]
Acute myeloid leukemia	Upregulation	Proliferation, apoptosis	–	Oncogene	[51]
Natural killer/T-cell lymphoma	Upregulation	Proliferation apoptosis, cell cycle	NF-kB, P53	Oncogene	[52]

ISSN: 1475-2867