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Table 1 Functional characterization of ZFAS1 in various tumors

From: ZFAS1: a novel tumor-related long non-coding RNA

Tumor type Expression Functional role Related gene Role References
Breast cancer Downregulation Tumor suppressor [16, 19, 21, 22]
Glioma Upregulation Proliferation, migration invasion, cell cycle, EMT process E-Cadherin, N-cadherin, Snail, MMP2, MMP9, Integrin β1, ZEB1, Twist, HES-1, NICD Oncogene [25, 26]
Colorectal cancer Upregulation Proliferation, cell cycle, invasion, apoptosis, EMT process miR-484, p53, cyclin B1, PARP, ZEB1, E-cadherin, ZO-1, Vimentin, N-cadherin Oncogene [30,31,32,33]
Gastric cancer Upregulation Proliferation, cell cycle, migration, apoptosis, EMT process N-Cadherin, Vimentin, ZEB1, Snail, MMP14, Twist, E-cadherin, EpCAM, Cyclin D1, Bcl2, Bax, Slug, Oncogene [37,38,39]
Hepatocellular carcinoma Upregulation/downregulation Proliferation, apoptosis, invasion, metastasis ZEB1, MMP-14, MMP16, miR-9, miR-150 Oncogene/tumor suppressor [41, 42]
Ovarian cancer Upregulation Proliferation, migration, chemoresistance miR-150, Sp1 Oncogene [45, 46]
Melanoma Upregulation Proliferation Ki67, PCNA, CyclinD1 Oncogene [47]
Non-small cell lung cancer Upregulation Oncogene [48]
Osteosarcoma Upregulation Proliferation, invasion miR-200b, miR-200c, BMI1, Sp1, ZEB2 Oncogene [49]
Esophageal squamous cell carcinoma Upregulation Oncogene [50]
Acute myeloid leukemia Upregulation Proliferation, apoptosis Oncogene [51]
Natural killer/T-cell lymphoma Upregulation Proliferation apoptosis, cell cycle NF-kB, P53 Oncogene [52]
  1. ZFAS1 ZNFX1 antisense RNA 1, EMT epithelial–mesenchymal transition