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Table 2 IC50 and resistance fold of breast cell lines in the present of sulbactam and doxorubicin

From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Cell line

IC50 of Doxorubicin (Dox, μM)

Resistance fold

Dox

Dox + Sul

Dox + Sul/Dox

MCF10A

2.51

2.50

1.00

BT474

1.14

0.54

0.47

MCF-7

0.69

0.37

0.54

MDA-MB-231

3.16

1.25

0.40

MDA-MB-361

0.89

0.46

0.51

MDA-MB-435

1.22

0.51

0.42

MDA-MB-453

0.69

0.27

0.39

MDA-MB-468

0.27

0.05

0.20

T47D

8.53

3.83

0.45

  1. IC50 was calculated from the results of Fig. 1 using CompuSyn. Resistance fold was determined by dividing the IC50 values of cells treated with doxorubicin and 2 mM sulbactam (Dox + Sul) by the IC50 of cells treated with doxorubicin (Dox)
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Cancer Cell International

ISSN: 1475-2867

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