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Table 2 IC50 and resistance fold of breast cell lines in the present of sulbactam and doxorubicin

From: Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Cell line IC50 of Doxorubicin (Dox, μM) Resistance fold
Dox Dox + Sul Dox + Sul/Dox
MCF10A 2.51 2.50 1.00
BT474 1.14 0.54 0.47
MCF-7 0.69 0.37 0.54
MDA-MB-231 3.16 1.25 0.40
MDA-MB-361 0.89 0.46 0.51
MDA-MB-435 1.22 0.51 0.42
MDA-MB-453 0.69 0.27 0.39
MDA-MB-468 0.27 0.05 0.20
T47D 8.53 3.83 0.45
  1. IC50 was calculated from the results of Fig. 1 using CompuSyn. Resistance fold was determined by dividing the IC50 values of cells treated with doxorubicin and 2 mM sulbactam (Dox + Sul) by the IC50 of cells treated with doxorubicin (Dox)