Fig. 4
From: BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription
BC094916 overexpression suppressed anti-apoptosis proteins Bcl2 and Mcl1, plasma cells-related proteins Blimp1, Myc, Aid, Bcl6, and Xbp-1, and up-regulated apoptosis protein p53 in SP 2/0 cells. The stable BC094916- and EGFP-expressing SP 2/0 cells (BC094916) and only EGFP-expressing SP 2/0 cells (vector) were cultured for 2Â days, collected and subject to immunoblot analysis with monoclonal anti-mouse Mcl1, p53, Blimp1, Myc, Aid, Bcl2, Bcl6, Xbp1 and GAPDH. Results represent three independent experiments