Fig. 4

Knockdown of miR-181b attenuated DLX6-AS1-mediated effects on pancreatic cancer cell proliferation, migration and invasion. a The expression of miR-181b in human pancreatic cancer cell lines and human pancreatic duct epithelial cell line (HPDE6-C7) was determined by qRT-PCR. b The expression of miR-181b in SW1990 and PANC-1 cells transfected inhibitor NC or miR-181b inhibitor was determined by qRT-PCR. The cell proliferation of c SW1990 and d PANC-1 cells co-transfected with siNC + inhibitor NC, siDLX6-AS1 + inhibitor NC, or siDLX6-AS1 + miR-181b inhibitor was determined by CCK-8 assay. e Cell growth, f cell migration and g cell invasion of SW1990 and PANC-1 cells co-transfected with siNC + inhibitor NC, siDLX6-AS1 + inhibitor NC, or siDLX6-AS1 + miR-181b inhibitor were determined by colony formation assay, Transwell migration assay and Transwell invasion assay, respectively. *P < 0.05 and ***P < 0.001