Fig. 2
BORIS function in sustaining cancer stem cell (CSC) properties. BORIS induces the expression of some important CSC markers such as ALDH1, ABCG2, hTERT, NANOG, OCT4 and SOX2 in cancer cells. BORIS is also recognized as an inducer of Wnt and Notch signaling pathways that play important roles in the maintenance of CSC properties such as self-renewal, tumor-sphere formation, chemoresistance, anchorage independent growth, and migration/invasion capacity