Table 3 The pooled HR and 95% CI for the prognostic value of Kindlin-2 expression
From: Prognostic value of Kindlin-2 expression in patients with solid tumors: a meta-analysis
Outcome group | Subgroup | No. of studies | No. of patients | Model | Pooled HR (95% CI) | P value of pooled HR | Heterogeneity | P value of meta-regression | |
|---|---|---|---|---|---|---|---|---|---|
I2 (%) | P value | ||||||||
Overall | |||||||||
 OS | Overall | 16 | 1869 | Fixed | 1.6612 [1.4400; 1.9164] | < 0.0001 | 36.3 | 0.0729 | – |
 DFS/RFS/PFS | 11 | 1374 | Random | 1.7309 [1.1643; 2.5733] | 0.0067 | 76.9 | < 0.0001 | ||
Sample size | |||||||||
 OS | ≥ 100 | 9 | 1433 | Random | 1.6074 [1.2435; 2.0777] | 0.0003 | 52.5 | 0.03 | 0.3455 |
< 100 | 7 | 436 | Fixed | 1.9081 [1.3873; 2.6245] | 0.0001 | 0.0 | 0.45 | ||
 DFS/RFS/PFS | ≥ 100 | 6 | 1009 | Random | 1.3943 [0.8759; 2.2194] | 0.1611 | 70.7 | < 0.01 | 0.2277 |
< 100 | 5 | 365 | Random | 2.2280 [1.1574; 4.2886] | 0.0165 | 78.0 | < 0.01 | ||
Tumor type (from which system) | |||||||||
 OS | Digestive | 9 | 780 | Fixed | 1.7955 [1.4224; 2.2664] | < 0.0001 | 0.0 | 0.79 | 0.5000 |
Non-digestive | 7 | 1089 | Random | 1.6305 [1.1236; 2.3662] | 0.0101 | 67.0 | < 0.01 | ||
 DFS/RFS/PFS | Digest | 7 | 622 | Random | 2.0137 [1.2856; 3.1542] | 0.0022 | 72.2 | < 0.01 | 0.3149 |
Non-digestive | 4 | 752 | Random | 1.3101 [0.5547; 3.0945] | 0.5378 | 81.9 | < 0.01 | ||
Sample type (from which tissue) | |||||||||
 OS | Cancer | 13 | 1492 | Random | 1.7897 [1.3855; 2.3118] | < 0.0001 | 46.1 | 0.03 | 0.5741 |
Stroma | 3 | 377 | Fixed | 1.5830 [1.1958; 2.0957] | 0.0013 | 0.0 | 0.57 | ||
 DFS/RFS/PFS | Cancer | 8 | 997 | Random | 1.8358 [1.0668; 3.1589] | 0.0283 | 83.4 | < 0.01 | 0.6650 |
Stroma | 3 | 377 | Fixed | 1.5566 [1.0726; 2.2590] | 0.0199 | 0.0 | 0.74 | ||
Max follow-up time (months) | |||||||||
 OS | ≥ 60 | 13 | 1509 | Random | 1.6442 [1.3212; 2.0462] | 0.0207 | 31.7 | 0.13 | 0.4370 |
< 60 | 3 | 360 | Random | 2.4020 [1.1431; 5.0471] | < 0.0001 | 66.3 | 0.05 | ||
 DFS/RFS/PFS | ≥ 60 | 9 | 1202 | Random | 1.4740 [0.9864; 2.2028] | 0.0583 | 76.7 | < 0.01 | 0.0258** |
< 60 | 2 | 172 | Fixed | 4.9891 [2.4072; 10.3405] | < 0.0001 | 0.0 | 0.53 | ||
HR extraction | |||||||||
 OS | COX | 11 | 1527 | Fixed | 1.7024 [1.4600; 1.9851] | < 0.0001 | 0.0 | 0.61 | 0.4737 |
Non-COX | 5 | 342 | Random | 1.6093 [0.7542; 3.4340] | 0.2185* | 72.7 | < 0.01 | ||
 DFS/RFS/PFS | COX | 8 | 1103 | Random | 2.2266 [1.5122; 3.2785] | < 0.0001 | 72.1 | < 0.01 | 0.0085** |
Non-COX | 3 | 271 | Random | 0.7158 [0.2982; 1.7182] | 0.4542* | 66.7 | 0.05 | ||
NOS score | |||||||||
 OS | ≥ 8 | 6 | 553 | Fixed | 1.6820 [1.3178; 2.1470] | < 0.0001 | 0.0 | 0.64 | 0.6371 |
|  | < 8 | 10 | 1316 | Random | 1.6701 [1.2539; 2.2243] | 0.0005 | 55.3 | 0.02 | |
 DFS/RFS/PFS | ≥ 8 | 3 | 198 | Random | 1.9211 [0.6133; 6.0179] | 0.2624* | 86.8 | < 0.01 | 0.6479 |
|  | < 8 | 8 | 1176 | Random | 1.6244 [1.0899; 2.4211] | 0.0172 | 69.8 | < 0.01 | |