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Table 3 The pooled HR and 95% CI for the prognostic value of Kindlin-2 expression

From: Prognostic value of Kindlin-2 expression in patients with solid tumors: a meta-analysis

Outcome group Subgroup No. of studies No. of patients Model Pooled HR (95% CI) P value of pooled HR Heterogeneity P value of meta-regression
I2 (%) P value
Overall
 OS Overall 16 1869 Fixed 1.6612 [1.4400; 1.9164] < 0.0001 36.3 0.0729
 DFS/RFS/PFS 11 1374 Random 1.7309 [1.1643; 2.5733] 0.0067 76.9 < 0.0001
Sample size
 OS ≥ 100 9 1433 Random 1.6074 [1.2435; 2.0777] 0.0003 52.5 0.03 0.3455
< 100 7 436 Fixed 1.9081 [1.3873; 2.6245] 0.0001 0.0 0.45
 DFS/RFS/PFS ≥ 100 6 1009 Random 1.3943 [0.8759; 2.2194] 0.1611 70.7 < 0.01 0.2277
< 100 5 365 Random 2.2280 [1.1574; 4.2886] 0.0165 78.0 < 0.01
Tumor type (from which system)
 OS Digestive 9 780 Fixed 1.7955 [1.4224; 2.2664] < 0.0001 0.0 0.79 0.5000
Non-digestive 7 1089 Random 1.6305 [1.1236; 2.3662] 0.0101 67.0 < 0.01
 DFS/RFS/PFS Digest 7 622 Random 2.0137 [1.2856; 3.1542] 0.0022 72.2 < 0.01 0.3149
Non-digestive 4 752 Random 1.3101 [0.5547; 3.0945] 0.5378 81.9 < 0.01
Sample type (from which tissue)
 OS Cancer 13 1492 Random 1.7897 [1.3855; 2.3118] < 0.0001 46.1 0.03 0.5741
Stroma 3 377 Fixed 1.5830 [1.1958; 2.0957] 0.0013 0.0 0.57
 DFS/RFS/PFS Cancer 8 997 Random 1.8358 [1.0668; 3.1589] 0.0283 83.4 < 0.01 0.6650
Stroma 3 377 Fixed 1.5566 [1.0726; 2.2590] 0.0199 0.0 0.74
Max follow-up time (months)
 OS ≥ 60 13 1509 Random 1.6442 [1.3212; 2.0462] 0.0207 31.7 0.13 0.4370
< 60 3 360 Random 2.4020 [1.1431; 5.0471] < 0.0001 66.3 0.05
 DFS/RFS/PFS ≥ 60 9 1202 Random 1.4740 [0.9864; 2.2028] 0.0583 76.7 < 0.01 0.0258**
< 60 2 172 Fixed 4.9891 [2.4072; 10.3405] < 0.0001 0.0 0.53
HR extraction
 OS COX 11 1527 Fixed 1.7024 [1.4600; 1.9851] < 0.0001 0.0 0.61 0.4737
Non-COX 5 342 Random 1.6093 [0.7542; 3.4340] 0.2185* 72.7 < 0.01
 DFS/RFS/PFS COX 8 1103 Random 2.2266 [1.5122; 3.2785] < 0.0001 72.1 < 0.01 0.0085**
Non-COX 3 271 Random 0.7158 [0.2982; 1.7182] 0.4542* 66.7 0.05
NOS score
 OS ≥ 8 6 553 Fixed 1.6820 [1.3178; 2.1470] < 0.0001 0.0 0.64 0.6371
  < 8 10 1316 Random 1.6701 [1.2539; 2.2243] 0.0005 55.3 0.02
 DFS/RFS/PFS ≥ 8 3 198 Random 1.9211 [0.6133; 6.0179] 0.2624* 86.8 < 0.01 0.6479
  < 8 8 1176 Random 1.6244 [1.0899; 2.4211] 0.0172 69.8 < 0.01
  1. *Means that the P value of pooled HR is more than 0.05
  2. **Means the P value from the test of moderators in the meta-regression is lower than 0.05